Evolutionary Rate Covariation (ERC) Analysis

Before beginning, it is strongly recommended to read the section on "How to Use ERC" in the Methods tab.

ERC measures correlated rates across a phylogeny, allowing for extraction of genes with similar evolutionary histories. High ERC values are typically observed between genes participating in a common pathway or that otherwise share functionality (1,2). Hence, ERC is a tool that can help identify new functional connections between genes (3). Please consult the references below for further description of ERC and its uses.

Diagram of ERC process


  1. Clark NL, Alani E, Aquadro CF. Evolutionary rate covariation reveals shared functionality and co-expression of genes. Genome Research. 2012; 22(4): 714-720. PMC3317153
  2. Clark NL, Alani E, Aquadro CF. Evolutionary rate covariation involving meiotic proteins results from fluctuating evolutionary pressure in yeasts and mammals. Genetics. 2013; 193(2): 529-538. PMC3567741
  3. Findlay GD, Sitnik JL, Wang W, Aquadro CF, Clark NL, Wolfner MF. Evolutionary Rate Covariation Identifies New Members of a Protein Network Required for Drosophila Female Post-Mating Responses. PLOS Genetics. 2014; 10(1): e1004108. PMC3894160
  4. Contact erc.analysis@gmail.com with questions or concerns.